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KMID : 0191120230380220170
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Journal of Korean Medical Science
2023 Volume.38 No. 22 p.170 ~ p.170
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A Nationwide Survey of mRNA COVID-19 Vaccinee’s Experiences on Adverse Events and Its Associated Factors
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Yoon Dong-Won
Jeon Ha-Lim
Noh Yun-Ha
Choe Young-June
Choe Seung-Ah
Jung Jae-Hun
Shin Ju-Young
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Abstract
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Background : Although coronavirus disease 2019 (COVID-19) vaccines have been distributed worldwide under emergency use authorization, the real-world safety profiles of mRNA vaccines still need to be clearly defined. We aimed to identify the overall incidence and factors associated with adverse events (AEs) following mRNA COVID-19 vaccination.
Methods : We conducted web-based survey from December 2 to 10 in 2021 with a 2,849 nationwide sampled panel. Study participants were individuals who had elapsed at least two-weeks after completing two dosing schedules of COVID-19 vaccination aged between 18?49 years. We weighted the participants to represent the Korean population. The outcome was the overall incidence of AEs following mRNA COVID-19 vaccination and associated factors. We estimated the weighted odds ratios (ORs) using multivariable logistic regression models to identify the factors associated with AEs.
Results : Of the 2,849 participants (median [interquartile range] age, 35 [27?42] years; 51.6% male), 90.8% (n = 2,582) for the first dose and 88.7% (n = 2,849) for the second dose reported AEs, and 3.3% and 4.3% reported severe AEs, respectively. Occurrence of AEs was more prevalent in mRNA-1273 (OR, 2.06; 95% confidence interval [CI], 1.59?2.67 vs. BNT162b2), female sex (1.88; 1.52?2.32), and those with dermatologic diseases (2.51; 1.32?4.77). History of serious allergic reactions (1.96; 1.06?3.64) and anticoagulant medication use (4.72; 1.92?11.6) were associated with severe AEs.
Conclusion : Approximately 90% of participants reported AEs following mRNA COVID-19 vaccination. Substantial factors, including vaccine type (mRNA-1273), female sex, and dermatologic diseases were associated with AEs. Our findings could aid policymakers in establishing vaccination strategies tailored to those potentially susceptible to AEs.
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KEYWORD
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COVID-19 Vaccines, Drug-Related Side Effects and Adverse Reactions, mRNA Vaccines, Risk Factors, Survey and Questionnaires
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